Leptin Mechanism
The attack murderer Flab
Does not take much of a look around to see that the incidence of obesity in America is a pandemic. The Centers for Disease Control and Prevention estimate that more than 25% of adults and over 15% of children and adolescents are obese. The result: signifi cannot health issues early death and the rising costs of health care. (1) While a cure for obesity still seems little more than a chimera, is a hot area of research, simply because of the profound effect it can have on American society. How many lives could be saved with a reduction in heart disease, diabetes and cancer? All of which are more common in the obese.
Hello – Is there anybody there?
There is a lot of focus in the hormone leptin, a peptide family of cytokines that occurs in both and released from fat cells (2).
Researchers have determined that the amount of leptin produced in humans and rodents is proportional to body fat. One would think this would be a good thing – it must offset the more leptin calories consumed. Somehow, it does not work that way …
The fact is that obese people become resistant to the effects of leptin, despite producing more of the same. Obviously, once the kick mutations in the gene for diabetes, leptin receptors become unresponsive. It is as if the message is being sent – the phone is ringing off the hook – but no one is home to answer the call (3).
Basically, leptin tells you when it's full and lets you know it's time stop eating. Leptin If your message does not happen – it happens to many people – you overeat, put in a lot of fat and the development of metabolic problems such as diabetes.
Forcing the connection of the Leptin Gene Therapy
Experiments have been conducted in rodents and humans. When Rats were fed a high fat diet (45% calories from fat) increased their weight by 32.7% in 9 weeks. In contrast, rats with a regular diet the same amount of time than a normal amount of weight – 17.1%. However, the group of high-fat diet were leptin treatment increased weight of only 9.1% despite their high fat diet (4).
The study concluded that the leptin gene therapy center can avoid rapid weight gain and hyperinsulinemia due to eating a diet rich in fats. Moreover, the treatment appears to have a long-term effect because it increases energy expenditure by promoting thermogenesis brown adipose tissue (brown fat), the natural mechanism to burn body fat. Therefore, gene therapy is a promising opportunity both to understand and treat weight adjustment process (5).
An unconventional idea
In an interesting turn of events, the researchers demonstrated they are really thinking outside the box.
A study published in the June 3, 2009 issue of Cell Metabolism said graduate student Jason Dean, a member of the research team directed by James Liao, saying: "We come with an unconventional idea that we borrowed from plants and bacteria … We know that plants and bacteria digest fats differently from humans, mammals. seed plants usually store large amounts of fat. When they germinate, convert fat into sugar for growth.
The reason why they can digest fat this way is because they have a group of enzymes that is only present in plants and bacteria. These enzymes are called 'glyoxylate shunt and are not present in mammals. (6)
Liao team cloned the genes of bacteria that may facilitate the derivation, then presented cloned genes in liver cells of mice. This allowed the cells to digest the fatty acid in half the normal time (7).
"We are very encouraging, "said lead researcher Liao." This is the first example of how people can build new genes in mammals to achieve desired function. It's very exciting that we have been able to achieve this new pathway in mammals that could be used to combat a serious problem. "
Obviously, a definitive solution to obesity and its associated metabolic problems remain relegated to the future. But it's very interesting to follow the ongoing investigations and stay on the cutting edge. What dreams may come true pipe.
I invite you to stay tuned for breaking news.
Please consult your personal physician before making changes to your diet or exercise and complete the routine.
Source:
- "The metabolic pathway engineering researchers in mice to prevent diet-induced obesity, "Physorg.com, June 2, 2009
- Sunter, David, et al, "Leptin: Your brain, appetite and obesity," British Society for Neuroendocrinology
- Sunter, David, et al, "Leptin: Your brain, appetite and obesity", British Society for Neuroendocrinology
- Dubel, MG, et al, "Central leptin gene therapy blocks high fat-induced weight gain diet, hyperleptinemia and hyperinsulinemia, Diabetes, June 2002 vol 51 no. 6 1729-1736
- Dubel, MG, et al, "Central leptin gene therapy blocks high fat diet-induced weight gain, hyperleptinemia and "hyperinsulinemia, diabetes, June 2002 vol 51 no. 6 1729-1736
- "Researchers metabolic pathway engineering in mice to prevent diet-induced obesity, "Physorg.com, June 2, 2009
- "Researchers in the metabolic pathway engineering mice to prevent diet-induced obesity, "Physorg.com, June 2, 2009
About the Author
Dr. Blankstein has been practicing for over 30 years as a leading Cardiologist. Trained in traditional medicine and Board Certified in both Internal Medicine and Cardiovascular Disease, he knows the importance of good medical care. This consideration has allowed him to discover safe and natural ways of healing. His dedication to bringing the latest and best in health solutions to his patients and the public has given him the experience to research and develop proven natural remedies for many illnesses.